北京索萊寶科技
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：K200050M
更新時間：2022-08-15
廠商性質：生產廠家
訪 問 量 ：1390
010-50973130
產品分類
Anti-EGFR Monoclonal Antibody
| 英文名稱 | Anti-EGFR Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 別名 | Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1 |
| 應用 | WB IF IHC |
| 稀釋比例 | WB 1:500-2000. IF 1:100-200. IHC 1:200-500. |
| 交叉反應 | Human |
| 蛋白分子量 | 170kDa |
| Gene ID | 1956 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted |
| Swiss Prot | P00533 |
| 克隆號 | 1B1 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues. |
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